Journal: AJOG Global Reports
Article Title: Prolonged detection of urine norfentanyl in individuals enrolled in a medication for opioid use disorder in pregnancy and postpartum program: a case series
doi: 10.1016/j.xagr.2024.100313
Figure Lengend Snippet: Urine norfentanyl levels and duration from last fentanyl use Urine norfentanyl levels on day 1 for case 2 (2293 ng/mL) and case 3 (15,234 ng/mL) are presented as axis maximum (>2000) for visibility of low level norfentanyl variability. Values at 2.5 ng/mL, marked by the horizontal line, represent values that were positive on fentanyl immunoassay. However, both fentanyl and norfentanyl were not quantifiable by liquid chromatography-tandem mass spectrometry. Values at 0 ng/mL reflect urine drug tests that were negative by fentanyl immunoassay.
Article Snippet: Fentanyl or norfentanyl confirmation was performed using LC-MS/MS, Agilent Infinity I 1190/6420 triple quadrupole analyzer, MRM analysis with Poroshell EC-C18 column, fentanyl-d5 (Cerilliant Corp, Round Rock, TX), and norfentanyl-d5 (Cerilliant Corporation, Round Rock, TX) internal standards and quantified using a 6-point calibration curve using weighted least squares regression.
Techniques: Liquid Chromatography, Mass Spectrometry